Diagnostic capabilities of optical coherence tomography and optical coherence tomography angiography in the diagnosis of primary open-angle glaucoma

  • N. S. Lutsenko State Institution «Zaporizhia Medical Academy of post-graduate education Ministry of Health of Ukraine», Zaporizhzhia, Ukraine
  • T. V. Nedilka Municipal non-profit enterprise ≪Zaporizhzhya Regional Clinical Hospital≫ of Zaporizhzhya Regional Council Zaporizhzhia, Ukraine
Keywords: optical coherence tomography angiography, ganglion complex, primary open-angle glaucoma, retinal vessel density, foveolar avascular zone, capillary peripapillary plexus

Abstract

Abstract. to assess the features of the retinal nerve fiber layer (RNFL), ganglion complex (GC) and the microcirculatory bed of the retina in patients with primary open-angle glaucoma (POAG) using optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA).

Materials and methods: The study involved 20 people (11 females, 9 males). Patients were divided into 2 groups. The first group included 10 clinically healthy individuals, the second group - 10 patients with POAG. All patients underwent standard ophthalmic examination, OCT / OCTA examination of the RNFL, GC and retinal microcirculatory bed.

Results: The study identified the most sensitive indicators to the progression of the glaucoma process. It was found that the RNFL thickness and the density of the retinal vascular progressively decrease with the development of glaucoma opticopathy. Compared with the group of healthy individuals in patients with POAG, the RNFL thickness in the lower temporal sector of the peripapillary zone was reduced by 44.04% (p <0,01). Compared with healthy individuals, the density of the superficial vascular plexus decreased by 16.3%, deep - by 12.5% ​​(p <0,01). The perimeter of the foveolar avascular zone in patients with glaucoma increased by 31.01%, the area of ​​the foveolar avascular zone increased 1.6 times (p <0.01).

Conclusions: OCT and OCTA are effective methods for assessing the state of GC, RNFL and microcirculatory bed of the retina, which allow for non-invasive monitoring and evaluation of these indicators in patients with POAG.

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Published
2022-03-20
How to Cite
Lutsenko, N. S., & Nedilka, T. V. (2022). Diagnostic capabilities of optical coherence tomography and optical coherence tomography angiography in the diagnosis of primary open-angle glaucoma. Modern Medical Technology, (1(52), 14-21. https://doi.org/10.34287/MMT.1(52).2022.3
Section
Original research