SERUM LEVEL OF SOME CYTOKINES IN CHILDREN 6-10 YEARS OLD WITH HIGH FREQUENCY OF ACUTE RESPIRATORY INFECTIONS

  • L. S. Ovcharenko State Institution «Zaporizhzhia Medical Academy of post-graduate education Ministry of Health of Ukraine», Zaporizhzhia, Ukraine
  • A. O. Vertegel State Institution «Zaporizhzhia Medical Academy of post-graduate education Ministry of Health of Ukraine», Zaporizhzhia, Ukraine
  • I. I. Redko State Institution «Zaporizhzhia Medical Academy of post-graduate education Ministry of Health of Ukraine», Zaporizhzhia, Ukraine
  • T. G. Andrienko State Institution «Zaporizhzhia Medical Academy of post-graduate education Ministry of Health of Ukraine», Zaporizhzhia, Ukraine
  • I. V. Samohin State Institution «Zaporizhzhia Medical Academy of post-graduate education Ministry of Health of Ukraine», Zaporizhzhia, Ukraine
  • O. V. Kryazhev State Institution «Zaporizhzhia Medical Academy of post-graduate education Ministry of Health of Ukraine», Zaporizhzhia, Ukraine
  • O. M. Chakmazova State Institution «Zaporizhzhia Medical Academy of post-graduate education Ministry of Health of Ukraine», Zaporizhzhia, Ukraine
Keywords: children, respiratory infections, immunity, cytokines, interleukins

Abstract

Objective: improved diagnosis of immune disorders in children aged 6-10 years old, who are often ill od upper respiratory tract infections (URTI), on the basis of these data, further investigation of serum equalities of cytokines, a way of diagnosing with indications in healthy children.

 Materials and methods. There were 60 children of 6 to 10 years of age, from which 2 groups were formed: 1). children who are often ill with URTI (n=30); 2). children, who do not get sick often URTI (n=30).

 Results. among children of 6-10 years of age, as often ill with URTI, the frequency of registration of high indications in place of interleukin-6 blood serum (by 53.3%, p<0.05), TNF (by 63.3%, p <0.05) and low indications for interleukin-10 (by 33.3%, p<0.05), it was established that there was a high probability (odds ratio) of an increase serum interleukin-6, TNF and a decrease in interleukin-10 as a reference value, it is associated with the presence of an increased incidence of URTI in children.

 Conclusion. in children aged 6-10 years, as they often fall ill with URTI, may tend to intensify pro-inflammation of the immune reactions, which still does not ensure a decrease in serious illness on URTI and unsafe side of the development of opportunistic diseases.

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Published
2022-06-10
How to Cite
Ovcharenko, L. S., Vertegel, A. O., Redko, I. I., Andrienko, T. G., Samohin, I. V., Kryazhev, O. V., & Chakmazova, O. M. (2022). SERUM LEVEL OF SOME CYTOKINES IN CHILDREN 6-10 YEARS OLD WITH HIGH FREQUENCY OF ACUTE RESPIRATORY INFECTIONS. Modern Medical Technology, (2(53), 15-18. https://doi.org/10.34287/MMT.2(53).2022.3
Section
Original research