INFLUENCE OF METABOLIC THERAPY ON LIFE QUALITY IN PATIENTS WITH ATRIAL FIBRILLATION PAROXYSMS

  • I.M. Fushtey State Institution “Zaporizhia Medical Academy of Post-Graduate Education Ministry of Health of Ukraine”
  • S.L. Podsevahina State Institution “Zaporizhia Medical Academy of Post-Graduate Education Ministry of Health of Ukraine”
  • A.I. Palamarchuk State Institution “Zaporizhia Medical Academy of Post-Graduate Education Ministry of Health of Ukraine”
  • E.S. Chabanna State Institution “Zaporizhia Medical Academy of Post-Graduate Education Ministry of Health of Ukraine”
Keywords: atrial fibrillation, medical cardioversion, amiodarone, magnesium orotate, life quality

Abstract

Abstract. The goal of the study was to investigate the effect of magnesium orotate as a part of complex therapy in sinus rhythm restoring in patients with AF paroxysm, as well as to evaluate its effectiveness and effect on LQo with long-term use.

Materials and research methods. We examined 56 patients (16 women and 40 men) with an average age of (61,5 ± 4,3) years with paroxysmal atrial fibrillation. All patients were divided into two groups. Patients of the 1st group (n=28) underwent medical cardioversion with amiodarone and magnesium orotate. Patients of the 2nd group (n=28) received only amiodarone. The time of sinus rhythm restoration, parameters of electrical instability of the atrial and ventricular myocardium after sinus rhythm restoration, patients life quality 3 months after discharge - were assessed in both groups.

Results. The study allowed to reveal that the addition of magnesium orotate to the basic therapy of patients with atrial fibrillation increases the effectiveness of medical cardioversion and reduces the time of its onset. When using amiodarone and magnesium orotate, signs of electrical instability of the atrial myocardium (the number of paired and supraventricular extrasystoles) are significantly less according to the results of Holter electrocardiogram monitoring compared with amiodarone monotherapy. Atrial fibrillation caused a life quality parameters deviations in the form of an increase in the severity of the disease symptoms, physical activity limitation and psycho-emotional sphere disorders. 3 months after the treatment, it was noted that life quality in patients of the 1st group (complex therapy using magnesium orotate) was higher compared to patients of the 2nd group due to the improvement in the indicators of the "psycho-emotional" component.

Conclusions. The addition of magnesium orotate to the basic therapy of paroxysmal atrial fibrillation can significantly improve the clinical course of the disease in patients and their life quality after 3 months treatment period.

References

Baryshnikova GA, Chorbinskaya SA, Stepanova II, Blokhina OE. Potassium and magnesium deficiency, its role in cardiovascular disease development and possibilities of correction. Consilium Medicum [Internet]. 2019;21(1):67-73. Available from: doi:10.26442/20751753.2019.1.190240.

Knyaz`kova II. Magnij v terapii serdechno-sosudisty`x zabolevanij. Zdorov'ya Ukraїni. 2018;2(57):60-61.

Pogozheva AV, Pogozheva AV. The role of potassium and magnesium for prevention and treatment of cardiovascular disease. Consilium Medicum [Internet]. 2020;22(10):76-79. Available from: doi:10.26442/20751753.2020.10.200336.

Ulubieva EA, Avtandilov AG. Effect of magnesium on the cardiovascular system in women. Rational Pharmacotherapy in Cardiology [Internet]. 2016;12(1):87-93. Available from: doi:10.20996/1819-6446-2016-12-1-87-93.

DiNicolantonio JJ, O’Keefe JH, Wilson W. Subclinical magnesium deficiency: a principal driver of cardiovascular disease and a public health crisis. Open Heart [Internet]. 2018;5(1):e000668. Available from: doi:10.1136/openhrt-2017-000668.

Guo Y, Wang H, Zhang H, Chen Y, Lip YH. Population-Based Screening or Targeted Screening Based on Initial Clinical Risk Assessment for Atrial Fibrillation: A Report from the Huawei Heart Study. Journal of Clinical Medicine [Internet]. 2020;9(5):1493. Available from: doi:10.3390/jcm9051493.

Kotalczyk A, Lip GY, Calkins H. The 2020 ESC Guidelines on the Diagnosis and Management of Atrial Fibrillation. Arrhythmia & Electrophysiology Review [Internet]. 2021;10(2):65-67. Available from: doi:10.15420/aer.2021.07.

Hughes G, Schneir A. Paroxysmal Atrial Fibrillation Associated With the Trigger Sequence of Strenous Exercise Followed By Cold Water Ingestion. The Journal of Emergency Medicine [Internet]. 2022;62(3):390-392. Available from: doi:10.1016/j.jemermed.2021.11.001.

Lip YH, Freedman B, De RC, Potpara TS. Stroke prevention in atrial fibrillation: Past, present and future. Thrombosis and Haemostasis [Internet]. 2017;117(07):1230-1239. Available from: doi:10.1160/th16-11-0876.

Mirica SN, Duicu OM, Trancota SL, Fira-Mladinescu O, Angoulvant D, Muntean DM. Magnesium orotate elicits acute cardioprotection at reperfusion in isolated and in vivo rat hearts. Canadian Journal of Physiology and Pharmacology [Internet]. 2013;91(2):108-115. Available from: doi:10.1139/cjpp-2012-0216.

Razzaque M. Magnesium: Are We Consuming Enough? Nutrients [Internet]. 2018;10(12):1863. Available from: doi:10.3390/nu10121863.

Schwalfenberg GK, Genuis SJ. The Importance of Magnesium in Clinical Healthcare. Scientifica [Internet]. 2017;2017:1-14. Available from: doi:10.1155/2017/4179326.

Turakhia MP, Desai M, Hedlin H, Rajmane A, Talati N, Ferris T, et al. Rationale and design of a large-scale, app-based study to identify cardiac arrhythmias using a smartwatch: The Apple Heart Study. American Heart Journal [Internet]. 2019;207:66-75. Available from: doi:10.1016/j.ahj.2018.09.002.

Yoon M, Yang P, Jang E, Yu HT, Kim T, Uhm J, et al. Improved Population-Based Clinical Outcomes of Patients with Atrial Fibrillation by Compliance with the Simple ABC (Atrial Fibrillation Better Care) Pathway for Integrated Care Management: A Nationwide Cohort Study. Thrombosis and Haemostasis [Internet]. 2019;119(10):1695-1703. Available from: doi:10.1055/s-0039-1693516.

Published
2022-09-30
How to Cite
Fushtey, I., Podsevahina, S., Palamarchuk, A., & Chabanna, E. (2022). INFLUENCE OF METABOLIC THERAPY ON LIFE QUALITY IN PATIENTS WITH ATRIAL FIBRILLATION PAROXYSMS. Modern Medical Technology, (3(54), 4-9. https://doi.org/10.34287/MMT.3(54).2022.1
Section
Original research