STIMULATION OF THE WOUND PROCESS IN LONG-TERM UNHEALED WOUNDS IN PATIENTS WITH DIABETIC FOOT SYNDROME

  • M. M. Militsa SI “Zaporizhia Medical Academy of Post-Graduate Education Ministry of Health of Ukraine”
  • V. V. Soldusova SI “Zaporizhia Medical Academy of Post-Graduate Education Ministry of Health of Ukraine”
  • K. M. Militsa SI “Zaporizhia Medical Academy of Post-Graduate Education Ministry of Health of Ukraine”
  • V. V. Steblyanko SI “Zaporizhia Medical Academy of Post-Graduate Education Ministry of Health of Ukraine”
  • V. S. Kazakov
  • M. D. Postolenko SI “Zaporizhia Medical Academy of Post-Graduate Education Ministry of Health of Ukraine”
Keywords: Long-term unhealed wound, wound defect, diabetic foot, platelet-enriched plasma (PRP), local therapy

Abstract

The purpose of the work. Compare the effectiveness of PRP and general accepted methods of local therapy for long-term unhealed wounds in patients with diabetic foot syndrome.

Materials and methods. A study was performed in 33 long-term patients unhealed wounds on the foot and leg in the neuropathic form of diabetic foot syndrome. Patients were divided into two groups depending on the nature of the received therapies - PRP and local therapy according to generally accepted principles. The effectiveness of therapy was assessed by the nature of changes in the microflora and c wound cell composition, as well as wound surface area on the 1st day, 8th and 22nd after starting treatment.

Results. The use of PRP allowed to observe on the 8th day regenerative-inflammatory type of cytogram, have manifestations of vascularization and epithelialization, reduce the number of patients with infected wounds by 2.7 times and reducing the wound surface area by 1.7 cm, which is 3.4 times more than in the second group (0.5 cm). The introduction of the second dose of PRP is even more stimulating reparative changes in the wound, manifested by the regenerative type of cytogram, reducing the number of infected wounds by 8 times, and reducing the area wound surface 2 times from the first measurement, while in the second group only on the 22nd day there were positive changes that were characteristic of the first group on the 8th day.

Conclusion. Thus, the use of PRP in therapy is long unhealed wounds in diabetic foot syndrome, is a promising area of ​​regenerative therapy. PRP is a way to obtain a natural concentration of internal factors of growth with minimal invasiveness and low costs. Proposed method of biological therapy in such patients is simple and affordable for both patient and for the doctor.

References

Abaev YuK. Treatment of chronic wounds, ulcers and bedsores. Zhurnal medical News. 2006; 6: 34–40

Chervyakov YuV, Staroverov IN, Nersesyan EG. Therapeutic angiogenesis in the treatment of patients with chronic obliterating diseases of the arteries of the lower extremities. Immediate and long-term results. Zhurnal fngiology and vascular surgery. 2012; 18: 19.

Deev RV, Mzhavanadze ND. Influence of a gene therapy inducer neoangiogenesis pvegf165 on macro and microhemodynamics in patients with chronic ischemia of the lower extremities of atherosclerotic genesis. Zhurnal science of the young. 2014; 1: 68-73.

Fenchin KM. Wound healing. Kyiv: Health; 1979. 168 р.

Finger MP. Biology of stem cells and cell technologies. Moscow: The medicine; 2009.

р.

Galstyan GR, Sergeeva SV, Ignatieva VI et al. Clinical economic justification for the cost of a quota for the treatment of patients with diabetic foot syndrome. Zhurnal diabetes. 2013; 3: 71-83

Galstyan GR, Dedov II, Avksent'eva MV et al. Clinical economic analysis of the use of the drug epidermal growth factor (Eberprotp®) in patients with diabetic foot syndrome. Zhurnal еndocrine surgery. 2013; 1: 4-15.

Gelfand BR. Surgical infections of the skin and soft tissues. Russian national recommendations. Ros. about-in surgeons. M. Med. inform. agency (MIA); 2015. 109 р

Glukhov AA. Structural and functional features of the healing of aseptic soft tissue wounds using platelet-enriched blood plasma. Zhurnal аngiology and vascular surgery. 2018; 6:

–9

Hammer A, Steiner S. Gene therapy for therapeutic angiogenesis in

peripheral arterial disease – a systematic review and meta-analysis of randomized, controlled trials. Vasa. 2013;42(5):331–339

Karlova VA. Wounds and wound infection. M: Medicine; 2003. 340 р.

Konenkov VI, Klimontov VV. Angiogenesis and vasculogenesis in diabetes diabetes: new concepts of pathogenesis and treatment of vascular complications. Zhurnal diabetes. 2012; 4: 17–27

Kosinets, AN, Kosinets VA, Pods YuV. Infection in surger. Minsk: Belarus. encycle. Im. P. Brocki; 2012. 496 р.

Kuzin MI, Kostyuchenok BM. Wounds and wound infection: a guide for doctors. Moscow, MEDGIZ; 1990. 592 p.

Malyutina NB. Rational application of early surgical treatment of deep burns in patients of older age groups. Zhurnal сombustiology. 2002; 10: 13-6

Popov P.A., Popov Yu.P., Magomedova L.A. et al. Treatment of complications after operations on the abdominal organs with using platelet-rich plasma. Zhurnal surgeon. 2014; 6: 4-11

Tiaka E.K., Papanas N., Manolakis A.C. et al. Epidermal growth factor in

the treatment of diabetic foot ulcers: an update. Perspectives in Vascular Surgery and Endovascular Therapy 2012; 24(1): 37-44.

Tolstov DA, Bogdan VG. Platelet concentrates: classification, production technologies, biological effects. Minsk: BSMU;2012, pp.141-4.

Titova MI. Modern methods of morphological and hemostasiological analysis of the reparative process in the wound using information software. Zhurnal сlinical laboratory diagnostics. 2000; 7: 24–36.

Published
2022-09-30
How to Cite
Militsa, M. M., Soldusova, V. V., Militsa, K. M., Steblyanko, V. V., Kazakov, V. S., & Postolenko, M. D. (2022). STIMULATION OF THE WOUND PROCESS IN LONG-TERM UNHEALED WOUNDS IN PATIENTS WITH DIABETIC FOOT SYNDROME. Modern Medical Technology, (3(54), 34-38. https://doi.org/10.34287/MMT.3(54).2022.7
Section
Original research