Possibilities of mathematical definition of unfavourable course of subarachnoid haemorrhage in the acute period

  • K. Y. Polkovnikova Comunal Institution «Zaporizhzhia Regional Clinical Hospital» of Zaporihzhy Regional Council
Keywords: notraumatic subarachnoid hemorrhage, C. S. Ogilvy, copeptin, SIADH syndrome, hyponatremia, prognosis, logistic regression


Subarachnoid haemorrhage (SAH) is associated with a 30-day mortality rate of 50% and is one of the most life-threatening cerebrovascular diseases.

Objective. Toevaluatetheprognosticsignificance and informativeness of some clinical indicators, highlighting the most optimal and reliable potential factors in the development of a mathematical equation for calculating the personal probability of complications in patients with subarachnoid hemorrhage of atraumatic etiology.

Materials and methods. A clinical experimental study involved 87 patients with SAH, 44 were men, 43 – women. On the first day after SAH, half of the patients were hospitalized – 46 people (52,87%).

Results. The constructed model for calculating the probability of events such as secondary ischemia, hydrocephalus, or cerebral vasospasm over the next 14 days indicates the correctness and adequacy of the constructed model of logistic regression.

The personal probability of a complication is calculated by the formula: p = 1 / (1 + e-z), where p is the % probability of a complication of SAH; z = –45,5 + 17,5* Copeptine –0.44 × Na + 0,06 × Age + 1,99 × Ball (Hunt-Hess).

Conclusions. The prognostic model allows us to consider that secondary ischemia and cerebral vasospasm are not only predictors of poor prognosis and potential factors for the formation of complications, but also are indicators for the correct determination of individual cumulative risk in SAH.


. Kowiański P, Lietzau G, Czuba E, Waśkow M, Steliga A, Moryś J. BDNF: A key factor with multipotent impact on brain signaling and synaptic plasticity. Cell Mol Neurobiol. 2018; 38 (3): 579–593. DOI: 10.1007/s10571-017-0510-4.

Tang J, Hu Q, Chen Y, Liu F, Zheng Y, Tang J, ZhangJ,ZhangJH.NeuroprotectiveroleofanN-acetyl serotonin derivative via activation of tropomyosin-related kinase receptor B after subarachnoid hemorrhage in a rat model. Neurobiol Dis. 2015; 78: 126–133. DOI: 10.1016/j.nbd.2015.01.009.

Agnihotri S, Czap A, Staff I, Fortunato G, McCullough LD. Peripheral leukocyte counts and outcomes after intracerebral hemorrhage. J Neuroinflammation. 2011; 8: 160. DOI: 10.1186/1742-2094-8-160.

Zweifel C, Katan M, Schuetz P et al. Copeptin is associated with mortality and outcome in patients with acute intracerebral hemorrhage. BMC Neurol. 2010; 10: 34. DOI: 10.1186/1471-2377-10-34.

Zhang X, Lu X-M, Huang L-F, Ye H. Copeptin is associated with one-year mortality and functional outcome in patients with acute spontaneous basal ganglia hemorrhage. Peptides. 2012; 33 (2): 336–341. DOI: 10.1016/j.peptides.2012.01.011.

Zhu XD, Chen JS, Zhou F, Liu QC, Chen G, Zhang JM. Detection of copeptin in peripheral blood of patients with aneurysmal subarachnoid hemorrhage. Crit Care. 2011; 15: R288. DOI: 10.1186/cc10575.

Chaichana KL, Pradilla G, Huang J, Tamargo RJ. Role of inflammation (leukocyte-endothelial cell interactions) in vasospasm after subarachnoid hemorrhage. World Neurosurg. 2010; 73: 22–41. DOI: 10.1016/j.surneu.2009.05.027.

Copeptin in aneurysmal subarachnoid hemorrhage. Tamargo RJ. Crit Care. 2012; 16 (1): 103. DOI: 10.1186/cc10594.

Juvela S, Siironen J. D-Dimer as an independent predictor for poor outcome after aneurysmal subarachnoid hemorrhage. Stroke. 2006; 37 (6): 1451–1456. DOI: 10.1161/01.STR.0000221710.55467.33.

Katan M, Christ-Crain M. The stress hormone copeptin: a new prognostic biomarker in acute illness. Swiss Med Wkly. 2010; 140: w13101. DOI: 10.4414/smw.2010.13101.

Morgenthaler NG, Struck J, Alonso C, Bergmann A. Assay for the measurement of copeptin, a stable peptide derived from the precursor of vasopressin. Clin Chem. 2006; 52 (1): 112–119. DOI: 10.1373/clinchem.2005.060038.

Zheng YK, Dong XQ, Du Q et al. Comparison of plasma copeptin and multiple biomarkers for assessing prognosis of patients with aneurysmal subarachnoid hemorrhage. Clin Chim Acta. 2017; 475: 64–69. DOI: 10.1016/j.cca.2017.10.009.

Zhang R, Liu J, Zhang Y. Association Between Circulating Copeptin Level and Mortality Risk in Patients with Intracerebral Hemorrhage: a Systemic Review and MetaAnalysis. Mol Neurobiol. 2017; 54 (1):169–174. DOI: 10.1007/s12035-015-9626-z.

How to Cite
Polkovnikova, K. Y. (2020). Possibilities of mathematical definition of unfavourable course of subarachnoid haemorrhage in the acute period. Modern Medical Technology, (1(44), 66-71. https://doi.org/10.34287/MMT.1(44).2020.10
Original research